1 Introduction
2 Proficiency Panel Program
3 Education
4 Publications
5 Members
6 Partners
7 Supporters

Publications and Communications


Reports from Proficiency Panels
  • Report phase IV/2008 (Intracellular cytokine staining - May 2009) (available upon request)
  • Report phase III/2007 (HLA-peptide multimer - Sept. 2008) (available upon request)
  • Report phase IV/2007 (ELISPOT - Aug. 2008) (available upon request)
  • Report phase II/2005 (ELISPOT and HLA-peptide multimers - Nov. 2006) (available upon request)
  • Report phase I/2005 (ELISPOT and HLA-peptide multimers -Oct. 2005) (available upon request)
Guidelines
  • First guidelines for tetramer staining (July 2007): (download)
  • First guidelines for IFN-γ ELISPOT (July 2007) (download)
Original Papers
  • Original Article: "The CIMT-monitoring panel: a two-step approach to harmonize the enumeration of antigen-specific CD8+ T lymphocytes by structural and functional assays."
    Cancer Immunol Immunother. 2008 Mar;57(3):289-302,
    A full text version of the article is available via Springer
Comments / letters
  • Commentary: "Toward the harmonization of immune monitoring in clinical trials: Quo vadis?"
    Cancer Immunol Immunother. 2008 Mar;57(3):285-8,
    A full text version of the article is available via Springer
  • Therapeutic Vaccines in Cancer, Moving from Immunomonitoring to Immunoguiding. Expert Review of Vaccines, 7 (1): 1-5.
Results from the CIMT Monitoring panel have been presented at the following meetings

2009:

  • iSBTc-FDA-NCI Workshop on Prognostic and Predictive Immunologic Biomarkers in Cancer, 28th October 2009, Washington, D.C., USA – Short introduction to “The Cancer immunotherapy Immunoguiding Program”
  • EORTC-GI group – Perspectives of Immunotherapy in GI cancer, 15-16 October 2009, Amsterdam, The Netherlands – Oral presentation – Harmonized T-cell monitoring assays for immunotherapy trials
  • Progress in Vaccination Against Cancer, PIVAC 9 meeting, 8–10 October 2009, Sofia, Bulgaria – Oral presentation - Update on the CIMT Immunoguiding Program
  • CIMT 2009, 3-5 June, Mainz, Germany - Oral presentations – CIP late break-out session: new and ongoing panels (Multimers, ELISPOT, ICS)

2008:

  • Joint ESCII Annual Meeting and PIVAC8 meeting – Recent advances in cancer immunotherapy with an emphasis on cancer, 9 - 10 October 2008, Athens, Greece – Oral presentation – “Harmonisation of T-cell monitoring: Report on the activities of the CIMT monitoring panel initiative”.
  • Cellular Mediated Immunity (CMI) standardization techniques in evaluation of vaccine response, 15 – 17 September 2008, Annency, France – Oral Presentation - "Harmonization of T cell immunomonitoring within the CIMT Monitoring Panel - correct protocol choices and additional sources of variation".
  • Annual Meeting of the Cancer Reserch Institute: Cancer Immunology & Immunotherapy 2008: From Discovery to Development to Drug, 15-17 September 2008, New York, USA - Oral presentation - “Harmonized T-cell monitoring assays as biomarkers for immunotherapy trials: a data driven approach by the CIMT Immunoguiding program (“CIP”)“
  • 9th International Conference on Chronic Myeloid and Lymphoid Malignancies, 29 -31 May 2008, Kazimierz Dolny, Poland - Oral Presentation - "Standardization of T cell immunomonitoring - protocol choices and additional sources of variation"
  • CIMT 2008, 15-16 May, Mainz, Germany - Oral presentations - "Updates on the CIMT immunomonitoring panel III (Multimers), panel IV (ELISPOT) and panel V (ICS)”
  • 9th International Symposium Biological Therapy of Cancer / From Disease to Targeted Therapy, 12-15 March 2008, Munich, Germany - Oral presentation - "Standardization of T cell immunomonitoring - correct protocol choices and additional sources of variation"
  • MASIR 2008 - Measurement of Antigen-Specific Immune Responses, 30 January - 2 February 2008, La Plagne, France - Oral presentation - "The CIMT-Monitoring panel: a two-step approach to harmonize the enumeration of antigen-specific CD8+ T lymphocytes"

2007

  • DC Therea Immunomonitoring Workshop, 6-7 December 2007, Brussels, Belgium - Oral presentations - "The CIMT-Monitoring panel: efforts towards the harmonization of T-cell monitoring"
    Part 1: Harmonizing/Optimizing assay protocols.
    Part 2: Harmonization of additional aspects needed?
  • Cancer Vaccines Adjuvants & Delivery SystemS - CVADD 2007 Conference, 10-12 October 2007, Heidelberg, Germany - Oral presentation: "The CIMT-Monitoring panel: a two-step approach to harmonize the enumeration of antigen-specific CD8+ T lymphocytes"
  • CVC Colloquium and Annual Meeting, 27-29 September 2007, Washington, USA - Oral presentation: "First Harmonization Criteria for Cellular Immune Response Assays for Cancer Vaccine Trials - Results from Two Large Proficiency Panels"
  • CIMT 2007, 12-14 April, Wuerzburg, Germany - Oral presentation: "Lessons learned from interlaboratory testing in phases I/2005 and II/2006"

2006

  • Symposium titled: "The need for standardisation of Immune Competence Assessment and Monitoring", 16 October 2006, Cardiff, Wales - Oral presentation: "Defining standardisation for immune monitoring"
  • CIMT 2006, 4-5 May 2006, Mainz, Germany - Poster abstract P04: "The CIMT Monitoring Panel: Enumeration of antigen-specific CD8+ T lymphocytes by structural and functional assays." Cancer Immunol Immunother. (2007) 56:406-407.
  • Progress in Vaccination against Cancer 2006 - PIVAC 6 conference, 28-29 September 2006, Granada, Spain - Oral presentation: "The CIMT monitoring panel: Standardization of in vitro methods for enumerating antigen specific CD8+ T lymphocytes".

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